Monoclonal antibodies for immunohistochemistry.

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Search by target protein or clone ID. Full datasheet, representative micrographs, and published performance data for each clone.

About TRPS1

TRPS1 (trichorhinophalangeal syndrome type 1) is a GATA-family zinc-finger transcription factor that has emerged as a sensitive immunohistochemical marker of breast origin. It is expressed across all molecular subtypes of breast carcinoma and shows particularly high sensitivity in triple-negative and basal-like disease, where it can exceed the sensitivity of the established marker GATA3. In diagnostic practice, TRPS1 IHC is used to help confirm or exclude a breast primary when evaluating metastatic carcinoma of uncertain origin.

TRPS1 staining is nuclear. As with any single marker, specificity is not absolute — a subset of non-breast tumors, particularly high-grade gynecologic carcinomas, can show TRPS1 positivity — so it is best interpreted as part of an antibody panel and in morphologic context. Anti-TRPS1 clone VB2A2 is a rabbit monoclonal antibody for IHC on formalin-fixed, paraffin-embedded human tissue; its performance in breast and gynecologic tumors has been characterized in the published studies below.

Independent literature

Peer-reviewed and meeting-presented studies on TRPS1 immunohistochemistry, including head-to-head clone comparisons. Full text is available from the original publisher.